The Minnesota Department of Health (MDH) provides essential health-based guidelines and regulations to assess potential health risks from chemical exposure in groundwater. This information is crucial for ensuring safe water consumption and protecting public health. For detailed information, please refer to the Guidance Values and Standards for Contaminants in Drinking Water or contact the Health Risk Assessment Unit for expert consultation.
Stay informed about the latest updates and guidelines by subscribing to Email Updates.
Understanding the Water Guidance Table
To effectively use the table below, it’s important to understand the key terms and categories:
Value Type Definitions:
- HRL (Health Risk Limit): These are regulatory limits set to protect human health, as detailed in Health Risk Limits.
- HBV (Health-Based Value): These are advisory values based on health considerations, further explained in Health-Based Values.
- RAA (Risk Assessment Advice): This is guidance provided based on risk assessment evaluations, also detailed in Risk Assessment Advice.
- The subscripts next to the value type indicate the year the value was developed (last two digits) or if the HRL is based on a US EPA Maximum Contaminant Level (MCL).
Exposure Duration Categories:
- Acute: Refers to exposure over a single day.
- Short-term: Exposure lasting from more than one day up to 30 days.
- Subchronic: Exposure lasting from more than 30 days up to 10% of a lifetime.
- Chronic: Exposure lasting greater than 10% of a lifetime.
- Cancer: Relates to lifetime exposure, from zero to 70 years of age, for carcinogenic substances.
Explore Further Resources
For a broader understanding of water safety and related guidelines, explore these resources:
- Other Minnesota Guidance: Access additional guidelines for specific substances and methods, including lead, dioxins, PAHs, Total Petroleum Hydrocarbons (TPH), and rapid assessment values for pesticides and pharmaceuticals.
- A Comparison of State Water Guidance and Federal Drinking Water Standards: Review a comparative analysis of state and federal drinking water standards.
- MDH Water Guidance and Additivity Calculator (Excel): Download the Excel-based calculator to evaluate individual or multiple contaminants across different exposure durations. This tool simplifies the assessment process and enhances your understanding of cumulative risks.
Human Health-Based Water Guidance Table
| Chemical CAS Number | Value Type | Exposure Duration | Value (µg/L) | Health Endpoint(s) |
|---|---|---|---|---|
| Find chemicals beginning with: A – C D – E F – M N – S T – Z | ||||
| Acenaphthene 83-32-9 Toxicological Summary for Acenaphthene (PDF) Information Sheet: Acenaphthene in Drinking Water (PDF) | HRL18 | Acute | ND | — |
| Short-term | ND | — | ||
| Subchronic | 200 | Adrenal;Liver system | ||
| Chronic | 100 | Adrenal;Liver system | ||
| Cancer | NA | — | ||
| Acetaminophen 103-90-2 Toxicological Summary for Acetaminophen (PDF) Information Sheet: Acetaminophen in Drinking Water (PDF) | HRL15 | Acute | 200 | Liver system |
| Short-term | 200 | Liver system | ||
| Subchronic | 200* | Liver system | ||
| Chronic | 200* | Liver system | ||
| Cancer | NA | — | ||
| Acetochlor 34256-82-1 Toxicological Summary for Acetochlor (PDF) See also degradates: Acetochlor ESA Acetochlor OXA Information Sheet: Acetochlor and Drinking Water (PDF) | HRL18 | Acute | ND | — |
| Short-term | 30 | Developmental;Liver system;Thyroid (E) | ||
| Subchronic | 30 | Liver system;Male reproductive system;Nervous system;Kidney system | ||
| Chronic | 20 | Liver system;Male reproductive system;Nervous system;Kidney system;Respiratory system | ||
| Cancer | NA | — | ||
| Acetochlor ESA (degradate of Acetochlor) 187022-11-3 Toxicological Summary for Acetochlor ESA (PDF) Information Sheet: Acetochlor ESA and Drinking Water (PDF) | HRL18 | Acute | ND | — |
| Short-term | 500 | Thyroid (E) | ||
| Subchronic | 500 | Male reproductive system;Thyroid (E) | ||
| Chronic | 300 | Male reproductive system;Thyroid (E) | ||
| Cancer | NA | — | ||
| Acetochlor OXA (degradate of Acetochlor) 184992-44-4 Toxicological Summary for Acetochlor OXA (PDF) Information Sheet: Acetochlor OXA and Drinking Water | HRL18 | Acute | ND | — |
| Short-term | 100 | Thyroid (E) | ||
| Subchronic | 100* | Thyroid (E) | ||
| Chronic | 90 | Thyroid (E) | ||
| Cancer | NA | — | ||
| Acetone 67-64-1 Toxicological Summary for Acetone (PDF) | HRL23 | Acute | ND | — |
| Short-term | 5,000 | Kidney system | ||
| Subchronic | 5,000* | Kidney system | ||
| Chronic | 3,000 | Blood system;Liver system;Kidney system | ||
| Cancer | NA | — | ||
| 6-Acetyl-1,1,2,4,4,7-hexamethyltetraline (AHTN or Tonalide) 21145-77-7 or 1506-02-1 Toxicological Summary for 6-Acetyl-1,12,4,4,7-hexamethyltetraline (PDF) Information Sheet: AHTN in Drinking Water (PDF) | HRL13 | Acute | ND | — |
| Short-term | 100 | Liver system | ||
| Subchronic | 30 | Liver system | ||
| Chronic | 20 | Liver system | ||
| Cancer | NA | — | ||
| Acrylamide 79-06-1 Toxicological Summary for Acrylamide (PDF) Information Sheet: Acrylamide in Drinking Water (PDF) | HRL15 | Acute | ND | — |
| Short-term | 7 | Developmental;Male reproductive system;Nervous system | ||
| Subchronic | 7* | Developmental;Male reproductive system;Nervous system | ||
| Chronic | 7* | Developmental;Male reproductive system;Nervous system | ||
| Cancer | 0.2 | Cancer | ||
| Alachlor 15972-60-8 Toxicological Summary for Alachlor (PDF) See also degradates Alachlor ESA Alachlor OXA Information Sheet: Alachlor and Drinking Water (PDF) | HRL18 | Acute | ND | — |
| Short-term | 100 | Developmental;Kidney system | ||
| Subchronic | 60 | Blood system;Liver system;Kidney system | ||
| Chronic | 9 | Blood system;Liver system;Kidney system | ||
| Cancer | NA | — | ||
| Alachlor ESA 142363-53-9 Toxicological Summary for Alachlor ESA (PDF) (degradate of Alachlor) | RAA16 | Acute | ND | — |
| Short-term | ND | — | ||
| Subchronic | 100 | Blood system | ||
| Chronic | 50 | Blood system | ||
| Cancer | NA | — | ||
| Alachlor OXA 171262-17-2 Toxicological Summary for Alachlor OXA (PDF) (degradate of Alachlor) | RAA16 | Acute | ND | — |
| Short-term | ND | — | ||
| Subchronic | 100 | Blood system | ||
| Chronic | 50 | Blood system | ||
| Cancer | NA | — | ||
| Aldicarb 116-06-3 | HRL93 | Chronic | 1 | Nervous system |
| Allyl chloride (3 chloropropene) 107-05-1 | HRL94 | Chronic | 30 | Nervous system |
| Aminomethylphosphonic acid (AMPA) 1066-51-9 Toxicological Summary for Aminomethylphosphonic acid (PDF) Information Sheet: AMPA and Drinking Water (PDF) | HRL23 | Acute | ND | — |
| Short-term | ND | — | ||
| Subchronic | 3000 | Liver system;Kidney system | ||
| Chronic | 1000 | Liver system;Kidney system | ||
| Cancer | NA | — | ||
| Anatoxin-a 64285-06-9 Toxicological Summary for Anatoxin-a (PDF) Information Sheet: Anatoxin-a in Drinking Water (PDF) | RAA16 | Acute | ND | — |
| Short-term | 0.1 | Nervous system | ||
| Subchronic | ND | — | ||
| Chronic | ND | — | ||
| Cancer | ND | — | ||
| Anthracene 120-12-7 Toxicological Summary for Anthracene (PDF) Information Sheet: Anthracene and Groundwater (PDF) | HRL93*** | Chronic | 2,000 | None |
| RAA19 | Acute | ND | — | |
| Short-term | ND | — | ||
| Subchronic | 1,000 | NA | ||
| Chronic | 600 | NA | ||
| Cancer | NA | — | ||
| Antimony 7440-36-0 | HRL93 | Chronic | 6 | — |
| Atrazine 1912-24-9 See also degradates Deethylatrazine, Deethyldeisopropylatrazine, and Deisopropylatrazine as described in the Toxicological Summary for Cyanazine and Atrazine Chlorinated Degradates (PDF) | HRLMCL | Chronic | 3 | see USEPA Organic Chemicals table |
| Barium 7440-39-3 | HRL93 | Chronic | 2,000 | Cardiovascular system |
| Bentazon 25057-89-0 Toxicological Summary for Bentazon (PDF) Information Sheet: Bentazon in Drinking Water (PDF) | HRL15 | Acute | 400 | Developmental;Female reproductive system |
| Short-term | 60 | Developmental | ||
| Subchronic | 50 | Blood system | ||
| Chronic | 30 | Thyroid | ||
| Cancer | NA | — | ||
| Benzene 71-43-2 Toxicological Summary for Benzene (PDF) | HRL09 | Acute | 10 | Developmental |
| Short-term | 10 | Blood system;Immune system | ||
| Subchronic | 3 | Blood system;Immune system | ||
| Chronic | 3** | Blood system;Immune system | ||
| Cancer | 2 | Cancer | ||
| Benzo[a]pyrene 50-32-8 Toxicological Summary for Benzo(a)pyrene (PDF) Information Sheet: Benzo(a)pyrene and Groundwater (PDF) | HRL23 | Acute | ND | — |
| Short-term | 0.5 | Developmental;Nervous system | ||
| Subchronic | 0.5* | Developmental;Nervous system | ||
| Chronic | 0.5* | Developmental;Nervous system | ||
| Cancer | 0.1 | Cancer | ||
| Go to > top . | ||||
| Benzoic acid 65-85-0 | HRL93 | Chronic | 30,000 | None |
| Benzophenone 119-61-9 Toxicological Summary for Benzophenone (PDF) Information Sheet: Benzophenone and Groundwater (PDF) | HRL23 | Acute | ND | — |
| Short-term | 900 | Developmental | ||
| Subchronic | 100 | Liver System;Kidney System | ||
| Chronic | 100** | Liver System;Kidney System | ||
| Cancer | NA | — | ||
| 1H-Benzotriazole 95-14-7 Toxicological Summary for 1H-Benzotriazole (PDF) Information Sheet: 1H-Benzotriazole, Tolyltriazole, 5-Methyl-1H-Benzotriazole and Groundwater (PDF) | HRL23 | Acute | ND | — |
| Short-term | 20 | Developmental | ||
| Subchronic | 20* | Developmental | ||
| Chronic | 20* | Developmental | ||
| Cancer | NA | — | ||
| methyl-1H-Benzotriazole (Tolyltriazole) 29385-43-1 Toxicological Summary for Tolyltriazole and 5-methyl-1H-Benzotriazole (PDF) Information Sheet: 1H-Benzotriazole, Tolyltriazole, 5-Methyl-1H-Benzotriazole and Groundwater (PDF) | RAA19 | Acute | ND | — |
| Short-term | 20 | Developmental | ||
| Subchronic | 20* | Developmental | ||
| Chronic | 20* | Developmental | ||
| Cancer | NA | — | ||
| 5-methyl-1H-Benzotriazole 136-85-6 Toxicological Summary for Tolyltriazole and 5-methyl-1H-Benzotriazole (PDF) Information Sheet: 1H-Benzotriazole, Tolytriazole, 5-Methyl-1H-Benzotriazole and Groundwater (PDF) | RAA19 | Acute | ND | — |
| Short-term | 20 | Developmental | ||
| Subchronic | 20* | Developmental | ||
| Chronic | 20* | Developmental | ||
| Cancer | NA | — | ||
| Beryllium 7440-41-7 | HRL93 | Cancer | 0.08 | Cancer |
| Biphenyl 92-52-4 Toxicological Summary for Biphenyl (PDF) | HRL23 | Acute | 400 | Kidney system |
| Short-term | 100 | Kidney system | ||
| Subchronic | 100* | Kidney system | ||
| Chronic | 100* | Kidney system | ||
| Cancer | 10 | Cancer | ||
| Bis(chloroethyl) ether (BCEE) 111-44-4 | HRL93 | Cancer | 0.3 | Cancer |
| Bis(chloromethyl) ether (BCME) 542-88-1 | HRL93 | Cancer | 0.002 | Cancer |
| Bisphenol A (BPA) 80-05-7 Toxicological Summary for Bisphenol A (PDF) Information Sheet: Bisphenol A in Drinking Water (PDF) | HRL15 | Acute | ND | — |
| Short-term | 100 | Developmental;Female reproductive system (E);Liver system;Male reproductive system (E);Kidney system;Thyroid (E) | ||
| Subchronic | 20 | Liver system;Kidney system | ||
| Chronic | 20** | Liver system;Kidney system | ||
| Cancer | NA | — | ||
| Boron 7440-42-8 Toxicological Summary for Boron (PDF) Information Sheet: Boron and Drinking Water (PDF) | RAA17 | Acute | ND | — |
| Short-term | 500 | Developmental | ||
| Subchronic | 500 | Developmental | ||
| Chronic | 500 | Developmental | ||
| Cancer | NA | — | ||
| Bromodichloromethane 75-27-4 Toxicological Summary for Bromodichloromethane (PDF) Information Sheet: Bromodichloromethane and Groundwater (PDF) | HRL23 | Acute | 400 | Female reproductive system (E) |
| Short-term | 30 | Immune system;Spleen | ||
| Subchronic | 30* | Immune system;Spleen | ||
| Chronic | 30 | Liver system | ||
| Cancer | 3 | Cancer | ||
| Bromoform 75-25-2 | HRL93 | Cancer | 40 | Cancer |
| Bromomethane (Methyl bromide) 74-83-9 | HRL93 | Chronic | 10 | Gastrointestinal system |
| n-Butanol 71-36-3 | HRL93 | Chronic | 700 | Nervous system |
| Butyl benzyl phthalate (BBP) 85-68-7 Toxicological Summary for Butyl benzyl phthalate (PDF) Information Sheet: Phthalates and Drinking Water (PDF) | HRL15 | Acute | 100 | Developmental (E) |
| Short-term | 100 | Developmental (E) | ||
| Subchronic | 100* | Developmental (E) | ||
| Chronic | 100* | Developmental (E) | ||
| Cancer | NA | — | ||
| Butylphthalyl butylglycolate (BPBG) 85-70-1 | HRL93 | Chronic | 7,000 | None |
| Cadmium 7440-43-9 Toxicological Summary for Cadmium (PDF) Information sheet: Cadmium and Drinking Water (PDF) | HRL15 | Acute | 5 | Developmental |
| Short-term | 1 | Developmental;Nervous system;Kidney system | ||
| Subchronic | 1 | Developmental;Skeletal | ||
| Chronic | 0.5 | Kidney system;Skeletal | ||
| Cancer | NA | — | ||
| Carbamazepine 298-46-4 Toxicological Summary for Carbamazepine (PDF) Information Sheet: Carbamazepine in Drinking Water (PDF) | HRL13 | Acute | 40 | Developmental;Nervous system |
| Short-term | 40 | Developmental;Blood system;Liver system;Immune system;Nervous system;Male reproductive system (E);Female reproductive system (E);Thyroid (E) | ||
| Subchronic | 40* | Developmental;Blood system;Liver system;Immune system;Nervous system;Male reproductive system (E);Female reproductive system (E);Thyroid (E) | ||
| Chronic | 40* | Developmental;Blood system;Liver system;Immune system;Nervous system;Male reproductive system (E);Female reproductive system (E);Thyroid (E) | ||
| Cancer | NA | — | ||
| Carbon disulfide 75-15-0 | HRL93 | Chronic | 700 | Developmental |
| Carbon tetrachloride 56-23-5 Toxicological Summary for Carbon tetrachloride (PDF) | HRL13 | Acute | 100 | Developmental;Liver system |
| Short-term | 3 | Liver system | ||
| Subchronic | 3* | Liver system | ||
| Chronic | 3* | Liver system | ||
| Cancer | 1 | Cancer | ||
| Chloramben 133-90-4 | HRL94 | Chronic | 100 | Liver system |
| Chlorobenzene 108-90-7 | HRL93 | Chronic | 100 | Liver system |
| Chloroethane 75-00-3 Toxicological Summary for Chloroethane (PDF) | RAA16 | Acute | ND | — |
| Short-term | ND | — | ||
| Subchronic | ND | — | ||
| Chronic | ND | — | ||
| Cancer | NA | — | ||
| Chloroform 67-66-3 Toxicological Summary for Chloroform (PDF) Information Sheet: Chloroform and Drinking Water (PDF) | HRL18 | Acute | ND | — |
| Short-term | 20 | Developmental;Liver system;Immune system | ||
| Subchronic | 20* | Developmental;Liver system;Immune system | ||
| Chronic | 20* | Developmental;Liver system;Immune system | ||
| Cancer | NA | — | ||
| 2-Chlorophenol 95-57-8 | HRL93 | Chronic | 30 | Developmental |
| Chlorothalonil 1897-45-6 | HRL94*** | Cancer | 30 | Cancer |
| Chlorothalonil 1897-45-6 Toxicological Summary for Chlorothalonil (PDF) Information Sheet: Chlorothalonil and 4-Hydroxychlorothalonil and Water (PDF) | HBV23 | Acute | ND | — |
| Short-term | 20 | Gastrointestinal system | ||
| Subchronic | 2 | Gastrointestinal system | ||
| Chronic | 1 | Gastrointestinal system, Hepatic (liver) system, Renal (kidney) system | ||
| Cancer | 6 | Cancer | ||
| Chlorpyrifos 2921-88-2 Toxicological Summary for Chlorpyrifos (PDF) Information Sheet: Chlorpyrifos and Drinking Water (PDF) | HBV13 | Acute | 2 | Nervous system |
| Short-term | 0.6 | Nervous system | ||
| Subchronic | 0.6* | Nervous system | ||
| Chronic | 0.6* | Nervous system | ||
| Cancer | NA | — | ||
| Chlorpyrifos Oxon (degradate of Chlorpyrifos) 5598-15-2 Toxicological Summary for Chlorpyrifos Oxon (PDF) Information Sheet: Chlorpyrifos and Drinking Water (PDF) | RAA13 | Acute | 0.9 | Nervous system |
| Short-term | 0.4 | Nervous system | ||
| Subchronic | 0.4* | Nervous system | ||
| Chronic | 0.4* | Nervous system | ||
| Cancer | NA | — | ||
| Chromium III 16065-83-1 | HRL94 | Chronic | 20,000 | None |
| Chromium VI 18540-29-9 | HRL93 | Chronic | 100 | None |
| Clothianidin 210880-92-5; 205510-53-8 Toxicological Summary for Clothianidin (PDF) Information Sheet: Clothianidin and Drinking Water (PDF) | HRL18 | Acute | ND | — |
| Short-term | 200 | Developmental | ||
| Subchronic | 200* | Developmental | ||
| Chronic | 200* | Developmental | ||
| Cancer | NA | — | ||
| Cumene (Isopropyl benzene) 98-82-8 | HRL93 | Chronic | 300 | None |
| Cyanazine 21725-46-2 Toxicological Summary for Cyanazine (PDF) See also degradates Cyanazine acid, Cyanazine amide, Deethylcyanazine, Deethylcyanazine acid, Deethylcyanazine amide, Deethyldeisopropylatrazine, and Deisopropylatrazine as described in the Toxicological Summary for Cyanazine and Atrazine Chlorinated Degradates (PDF). | HRL18 | Acute | 3 | Developmental;Female reproductive system |
| Short-term | 3 | Developmental;Female reproductive system | ||
| Subchronic | 3 | Developmental;Female reproductive system;Liver system;Kidney system | ||
| Chronic | 1 | None | ||
| Cancer | NA | — | ||
| Cyanazine acid (CAC) and Cyanazine amide (CAM) (degradates of Cyanazine) 36576-43-9; 36576-42-8 Toxicological Summary for Cyanazine and Atrazine Chlorinated Degradates (PDF) | RAA20 | Acute | 3 | Developmental;Female reproductive system |
| Short-term | 3 | Developmental;Female reproductive system | ||
| Subchronic | 3 | Developmental;Female reproductive system;Liver system;Kidney system | ||
| Chronic | 1 | None | ||
| Cancer | NA | — | ||
| Cyanide, free 57-12-5 | HRL93 | Chronic | 100 | Nervous system;Thyroid (E) |
| Go to > top . | ||||
| Deethylatrazine (DEA) (degradate of Atrazine) 6190-65-4 Toxicological Summary for Cyanazine and Atrazine Chlorinated Degradates (PDF) | RAA20 | Chronic | 3 | None |
| Deethylcyanazine (DEC), Deethylcyanazine acid (DCAC), and Deethylcyanazine amide (DCAM) (degradates of Cyanazine) 21725-40-6; 36749-35-6;36556-77-1 Toxicological Summary for Cyanazine and Atrazine Chlorinated Degradates (PDF) | RAA20 | Acute | 3 | Developmental;Female reproductive system |
| Short-term | 3 | Developmental;Female reproductive system | ||
| Subchronic | 3 | Developmental;Female reproductive system;Liver system;Kidney system | ||
| Chronic | 1 | None | ||
| Cancer | NA | — | ||
| Deethyldeisopropylatrazine (DACT, DEDI, DDA) and Deisopropylatrazine (DIA) (degradates of Atrazine and Cyanazine) 3397-62-4; 1007-28-9 Toxicological Summary for Cyanazine and Atrazine Chlorinated Degradates (PDF) | RAA20 | Use Cyanazine HRL values if Cyanazine, CAC, CAM, DEC, DCAC or DCAM are present. Use Atrazine HRL value if Cyanazine, CAC, CAM, DEC, DCAC or DCAM are not present. | ||
| Desvenlafaxine 93413-62-8; 386750-22-7;300827-87-6; 93414-04-1 Toxicological Summary for Desvenlafaxine (PDF) Information Sheet: Venlafaxine and Desvenlafaxine and Drinking Water (PDF) | HBV15 | Acute | ND | — |
| Short-term | 20 | Developmental;Gastrointestinal system;Male reproductive system;Nervous system (E) | ||
| Subchronic | 20* | Developmental;Gastrointestinal system;Male reproductive system;Nervous system (E) | ||
| Chronic | 20* | Developmental;Gastrointestinal system;Male reproductive system;Nervous system (E) | ||
| Cancer | NA | — | ||
| Dibromochloromethane 124-48-1 | HRL93 | Chronic | 10 | Liver system |
| 1,2-Dibromoethane (ethylene dibromide, EDB) 106-93-4 | HRL93*** | Cancer | 0.004 | Cancer |
| 1,2-Dibromoethane (ethylene dibromide, EDB) 106-93-4 Toxicological Summary for 1,2-Dibromoethane (ethylene dibromide, EDB) (2023) (PDF) Information Sheet: Ethylene Dibromide and Water (EDB) (PDF) | HBV23 | Acute | ND | — |
| Short-term | 10 | Female reproductive system,Hepatic (liver) systemImmune system,Male reproductive system,Renal (kidney) system,Respiratory system,Spleen | ||
| Subchronic | 10* | Female reproductive system,Hepatic (liver) system,Immune system,Male reproductive system,Renal (kidney) system,Respiratory system,Spleen | ||
| Chronic | 9 | Female reproductive system,Hepatic (liver) system,Immune system,Male reproductive system,Respiratory system | ||
| Cancer | 0.03 | Cancer | ||
| Dibutyl phthalate (DBP) 84-74-2 Toxicological Summary for Dibutyl phthalate (PDF) Information Sheet: Phthalates and Drinking Water (PDF) | HRL15 | Acute | 20 | Developmental (E) |
| Short-term | 20 | Developmental (E) | ||
| Subchronic | 20* | Developmental (E) | ||
| Chronic | 20* | Developmental (E) | ||
| Cancer | NA | — | ||
| Dicamba 1918-00-9 | HRL93*** | Chronic | 200 | Developmental |
| 1,2-Dichlorobenzene 95-50-1 | HRL93 | Chronic | 600 | Liver system |
| 1,4-Dichlorobenzene 106-46-7 Toxicological Summary for 1,4-Dichlorobenzene (PDF) Information Sheet: 1,4-Dichlorobenzene and Groundwater (PDF) | HRL23 | Acute | ND | — |
| Short-term | 50 | Developmental;Liver system;Nervous system | ||
| Subchronic | 50* | Developmental;Liver system;Nervous system | ||
| Chronic | 50* | Developmental;Liver system;Nervous system | ||
| Cancer | NA | — | ||
| 3,3′-Dichlorobenzidine 91-94-1 | HRL93 | Cancer | 0.8 | Cancer |
| Dichlorodifluoromethane 75-71-8 Toxicological Summary for Dichlorodifluoromethane (PDFs) | HRL11*** | Acute | ND | — |
| Short-term | ND | — | ||
| Subchronic | ND | — | ||
| Chronic | 700 | None | ||
| Cancer | NA | — | ||
| Dichlorodifluoromethane 75-71-8 Toxicological Summary for Dichlorodifluoromethane (PDF) Information Sheet: Dichlorodifluoromethane and Drinking Water (PDF) | RAA17 | Acute | ND | — |
| Short-term | ND | — | ||
| Subchronic | ND | — | ||
| Chronic | 500 | None | ||
| Cancer | NA | — | ||
| p,p’-Dichlorodiphenyldichloroethane (DDD) 72-54-8 | HRL93 | Cancer | 1 | Cancer |
| p,p’-Dichlorodiphenyldichloroethylene (DDE) 72-55-9 | HRL93 | Cancer | 1 | Cancer |
| p,p’-Dichlorodiphenyltrichloroethane (DDT) 50-29-3 | HRL93 | Cancer | 1 | Cancer |
| 1,1-Dichloroethane 75-34-3 Toxicological Summary for 1,1-Dichloroethane (PDF) | RAA16 | Acute | ND | — |
| Short-term | 400 | Nervous system | ||
| Subchronic | 400* | Nervous system | ||
| Chronic | 80 | Nervous system | ||
| Cancer | NA | — | ||
| 1,2-Dichloroethane 107-06-2 Toxicological Summary for 1,2-Dichloroethane (PDF) | HRL13 | Acute | ND | — |
| Short-term | 200 | Liver system | ||
| Subchronic | 200* | Liver system | ||
| Chronic | 60 | Kidney system;Liver system | ||
| Cancer | 1 | Cancer | ||
| cis-1,2-Dichloroethene 156-59-2 Toxicological Summary for cis-1,2-Dichloroethene (PDF) Information sheet: cis-1,2-Dichloroethene and Drinking Water (PDF) | HRL18 | Acute | ND | — |
| Short-term | 20 | Liver system | ||
| Subchronic | 10 | Kidney system | ||
| Chronic | 6 | Kidney system | ||
| Cancer | NA | — | ||
| trans-1,2-Dichloroethene 156-60-5 Toxicological Summary for trans-1,2-Dichloroethene (PDF) | HRL23 | Acute | ND | — |
| Short-term | ND | — | ||
| Subchronic | 50 | Immune system | ||
| Chronic | 9 | Immune system | ||
| Cancer | NA | — | ||
| 1,1-Dichloroethylene (Vinylidene chloride) 75-35-4 Toxicological Summary for 1,1-Dichloroethylene (Vinylidene chloride) (PDF) Information Sheet: 1,1-Dichloroethylene and Groundwater (PDF) | HRL23 | Acute | ND | — |
| Short-term | ND | — | ||
| Subchronic | 200 | Liver system | ||
| Chronic | 200 | Liver system | ||
| Cancer | NA | — | ||
| Dichlorofluoromethane (DCFM) 75-43-4 Toxicological Summary for Dichlorofluoromethane (PDF) Information sheet: Dichlorofluoromethane and Drinking Water (PDF) | RAA17 | Acute | ND | — |
| Short-term | 20 | Developmental;Liver system;Immune system | ||
| Subchronic | 20* | Developmental;Liver system;Immune system; | ||
| Chronic | 20* | Developmental;Liver system;Immune system | ||
| Cancer | NA | — | ||
| Dichloromethane (Methylene chloride) 75-09-2 | HRLMCL | Chronic | 5 | see USEPA Organic Chemicals table |
| 2,4-Dichlorophenol 120-83-2 | HRL93 | Chronic | 20 | Immune system |
| 2,4-Dichlorophenoxyacetic acid (2,4-D) 94-75-7 Toxicological Summary for 2,4-Dichlorophenoxyacetic acid (PDF) Information Sheet: 2.4-D and Drinking Water (PDF) | HRL18 | Acute | ND | — |
| Short-term | 30 | Adrenal;Developmental;Thyroid (E) | ||
| Subchronic | 30* | Adrenal;Developmental;Thyroid (E) | ||
| Chronic | 30* | Adrenal;Developmental;Thyroid (E) | ||
| Cancer | ND | — | ||
| 1,2-Dichloropropane 78-87-5 Toxicological Summary for 1,2-Dichloropropane (PDF) | HRL23 | Acute | ND | — |
| Short-term | 20 | Developmental | ||
| Subchronic | 20* | Developmental | ||
| Chronic | 20* | Developmental | ||
| Cancer | 3 | Cancer | ||
| 1,3-Dichloropropene 542-75-6 | HRL94 | Cancer | 2 | Cancer |
| Dieldrin 60-57-1 Toxicological Summary for Dieldrin (PDF) Information Sheet: Dieldrin and Drinking Water (PDF) | HRL18 | Acute | ND | — |
| Short-term | 0.2 | Developmental;Immune system;Nervous system | ||
| Subchronic | 0.2* | Developmental;Immune system;Nervous system | ||
| Chronic | 0.2 | Developmental;Liver system;Immune system;Nervous system | ||
| Cancer | 0.006 | Cancer | ||
| N,N-Diethyl-meta-toluamide (DEET) 134-62-3 Toxicological Summary for N,N-Diethyl-meta-toluamide (DEET) (PDF) Information Sheet: DEET in Drinking Water (PDF) | HRL13 | Acute | ND | — |
| Short-term | 200 | Developmental;Nervous system | ||
| Subchronic | 200* | Developmental;Nervous system | ||
| Chronic | 200* | Developmental;Nervous system | ||
| Cancer | NA | — | ||
| Go to > top . | ||||
| Di(2-ethylhexyl)phthalate (DEHP) 117-81-7 Toxicological Summary for Di(2-ethylhexyl) phthalate (PDF) Information Sheet: Phthalates and Drinking Water (PDF) | HRL15 | Acute | 20 | Developmental (E);Male reproductive system (E) |
| Short-term | 20 | Developmental (E);Male reproductive system (E) | ||
| Subchronic | 20* | Developmental (E);Male reproductive system (E) | ||
| Chronic | 20* | Developmental (E);Male reproductive system (E) | ||
| Cancer | 7 | Cancer | ||
| Diethyl phthalate 84-66-2 | HRL93 | Chronic | 6,000 | None |
| Diketonitrile (DKN) (Degradate of Isoxaflutole) 143701-75-1 Toxicological Summary for Diketonitrile (DKN) (PDF) Information Sheet: Isoxaflutole, Diketonitrile and Water (PDF) | RAA24 | Acute | ND | — |
| Short-term | 20 | Liver system | ||
| Subchronic | 10 | Liver system | ||
| Chronic | 7 | Liver system | ||
| Cancer | NA | — | ||
| Dimethenamid & Dimethenamid-P 87674-68-8; 163515-14-8 Toxicological Summary for Dimethenamid & Dimethenamid-P (PDF) Information Sheet: Dimethenamid and Drinking Water (PDF) See also degradates: Dimethenamid ESA & Dimethenamid OXA (PDF) | HRL15 | Acute | ND | — |
| Short-term | 600 | Developmental;Liver system;Nervous system;Female reproductive system | ||
| Subchronic | 600* | Developmental;Liver system;Nervous system;Female reproductive system | ||
| Chronic | 300 | Liver system | ||
| Cancer | NA | — | ||
| Dimethenamid ESA Dimethenamid OXA 205939-58-8; 380412-59-9 Toxicological Summary for Dimethenamid Degradates: ESA and OXA (PDF) Information Sheet: Dimethenamid and Drinking Water (PDF) | RAA13 | Acute | ND | — |
| Short-term | 600 | Developmental;Liver system;Nervous system;Female reproductive system | ||
| Subchronic | 600 | Developmental;Liver system;Nervous system;Female reproductive system | ||
| Chronic | 300 | Liver system | ||
| Cancer | NA | — | ||
| 2,4-Dimethylphenol 105-67-9 | HRL93 | Chronic | 100 | Blood system;Nervous system |
| Dimethylphthalate 131-11-3 | HRL94 | Chronic | 70,000 | Kidney system |
| 2,4-Dinitrophenol 51-28-5 | HRL94 | Chronic | 10 | Eyes |
| Dinoseb 88-85-7 Toxicological Summary for Dinoseb (PDF) Information Sheet: Dinoseb and Drinking Water (PDF) | HRL18 | Acute | ND | — |
| Short-term | 8 | Developmental | ||
| Subchronic | 8* | Developmental | ||
| Chronic | 8* | Developmental | ||
| Cancer | NA | — | ||
| 1,4-Dioxane 123-91-1 Toxicological Summary for 1,4-Dioxane (PDF) Information Sheet: 1,4-Dioxane in Drinking Water (PDF) | HRL13 | Acute | ND | — |
| Short-term | ND | — | ||
| Subchronic | 300 | Liver system;Kidney system;Respiratory system | ||
| Chronic | 100 | Liver system;Kidney system;Respiratory system | ||
| Cancer | 1 | Cancer | ||
| Disulfoton 298-04-4 | HRL94 | Chronic | 0.3 | Nervous system |
| 17α-Ethinylestradiol 57-63-6 Toxicological Summary for 17α-Ethinylestradiol (PDF) Information Sheet: 17α-Ethinylestradiol and Mestranol and Drinking Water (PDF) | HRL23 | Acute | ND | — |
| Short-term | 0.0005 | Developmental (E);Female Reproductive system (E);Male Reproductive system (E) | ||
| Subchronic | 0.0002 | Developmental | ||
| Chronic | 0.0002 | Developmental | ||
| Cancer | ND | — | ||
| Ethylbenzene 100-41-4 Toxicological Summary for Ethylbenzene (PDF) Information Sheet: Ethylbenzene and Groundwater (PDF) | HRL23 | Acute | ND | — |
| Short-term | 40 | Liver system;Kidney system | ||
| Subchronic | 40* | Liver system;Kidney system | ||
| Chronic | 40* | Liver system;Kidney system | ||
| Cancer | NA | — | ||
| *S***-Ethyl-N,N-dipropylthiocarbamate (EPTC)* 759-94-4 [Toxicological Summary for S-Ethyl-N,N-dipropylthiocarbamate (PDF) ](/communities/environment/risk/docs/guidance/gw/eptcsumm.pdf) [Information Sheet: S-Ethyl-N,N*-dipropylthiocarbamate (EPTC) and Drinking Water (PDF) ](/communities/environment/risk/docs/guidance/gw/eptcinfo.pdf) | HRL18 | Acute | 300 | Nervous system |
| Short-term | 300 | Developmental;Female reproductive system;Nervous system | ||
| Subchronic | 90 | Cardiovascular system | ||
| Chronic | 40 | Cardiovascular system | ||
| Cancer | NA | — | ||
| Ethyl ether 60-29-7 Toxicological Summary for Ethyl ether (PDF) | RAA16 | Acute | ND | — |
| Short-term | ND | — | ||
| Subchronic | 1000 | Liver system;Kidney system | ||
| Chronic | 200 | Liver system;Kidney system | ||
| Cancer | NA | — | ||
| Ethylene glycol 107-21-1 Toxicological Summary for Ethylene glycol (PDF) | HRL23 | Acute | ND | — |
| Short-term | 2,000 | Developmental | ||
| Subchronic | 2,000 | Developmental;Kidney system | ||
| Chronic | 2,000 | Developmental;Male reproductive system;Kidney system | ||
| Cancer | NA | — | ||
| Fluoranthene 206-44-0 Toxicological Summary for Fluoranthene (PDF) Information Sheet: Fluoranthene in Drinking Water (PDF) | HRL18 | Acute | ND | — |
| Short-term | ND | — | ||
| Subchronic | 200 | Liver system;Kidney system | ||
| Chronic | 70 | Liver system;Kidney system | ||
| Cancer | NA | see Guidance for Evaluating the Cancer Potency of PAH Mixtures (PDF) | ||
| Fluorene (9H-Fluorene) 86-73-7 Toxicological Summary for Fluorene (PDF) Information Sheet: Fluorene and Groundwater (PDF) | HRL23 | Acute | ND | — |
| Short-term | ND | — | ||
| Subchronic | 200 | Blood system;Spleen | ||
| Chronic | 80 | Blood system;Spleen | ||
| Cancer | NA | — | ||
| Fomesafen 72178-02-0 Toxicological Summary for Fomesafen (PDF) | HRL23 | Acute | ND | — |
| Short-term | 200 | Developmental;Liver system;Immune system | ||
| Subchronic | 200* | Developmental;Liver system;Immune system | ||
| Chronic | 20 | Liver system | ||
| Cancer | NA | — | ||
| Formaldehyde 50-00-0 | HRL94 | Chronic | 1,000 | Gastrointestinal system |
| Glyphosate 1071-83-6; 38641-94-0;40465-76-7; 34494-04-7;114370-14-8; 39600-42-5 Toxicological Summary for Glyphosate (PDF) Information Sheet: Glyphosate and Drinking Water (PDF) | HBV17 | Acute | ND | — |
| Short-term | 1,000 | Developmental | ||
| Subchronic | 1,000 | Gastrointestinal system | ||
| Chronic | 500 | Gastrointestinal system | ||
| Cancer | NA | — | ||
| Heptachlor 76-44-8 | HRL93 | Cancer | 0.08 | Cancer |
| Heptachlor epoxide 1024-57-3 | HRL93 | Cancer | 0.04 | Cancer |
| Hexachlorobenzene 118-74-1 | HRL93 | Cancer | 0.2 | Cancer |
| Hexachlorobutadiene 87-68-3 | HRL93 | Chronic | 1 | Kidney system |
| Hexane (n-hexane) 110-54-3 Toxicological Summary for n-Hexane (2022) (PDF) | RAA22 | Acute | ND | — |
| Short-term | 100 | Nervous system | ||
| Subchronic | 100* | Nervous system | ||
| Chronic | 80 | Nervous system | ||
| Cancer | NA | — | ||
| 4-Hydroxychlorothalonil 28343-61-5 Toxicological Summary for 4-Hydroxychlorothalonil (PDF) Information Sheet: Chlorothalonil and 4-Hydroxychlorothalonil and Water (PDF) | RAA23 | Acute | ND | — |
| Short-term | 2 | Developmental | ||
| Subchronic | 2* | Developmental | ||
| Chronic | 2* | Developmental | ||
| Cancer | NA | — | ||
| Imidacloprid 138261-41-3 Toxicological Summary for Imidacloprid (PDF) Information Sheet: Imidacloprid and Groundwater (PDF) | HRL23 | Acute | 100 | Nervous system |
| Short-term | 2 | Immune system | ||
| Subchronic | 2* | Immune system | ||
| Chronic | 2* | Immune system | ||
| Cancer | NA | — | ||
| Isobutanol 78-83-1 Toxicological Summary for Isobutanol (PDF) Information Sheet: Isobutanol and Drinking Water (PDF) | HBV16 | Acute | ND | — |
| Short-term | ND | — | ||
| Subchronic | 700 | Male reproductive system | ||
| Chronic | 300 | Male reproductive system | ||
| Cancer | NA | — | ||
| Isophorone 78-59-1 | HRL93 | Chronic | 100 | Kidney system |
| Isoxaflutole 141112-29-0 Toxicological Summary for Isoxaflutole (PDF) Information Sheet: Isoxaflutole, Diketonitrile and Water (PDF) See also degradate: Diketonitrile (DKN) | HBV24 | Acute | ND | — |
| Short-term | 20 | Liver system | ||
| Subchronic | 10 | Liver system | ||
| Chronic | 7 | Liver system | ||
| Cancer | NA | — | ||
| Linuron 330-55-2 | HRL93 | Chronic | 1 | Blood system |
| Manganese 7439-96-5 Toxicological Summary for Manganese (PDF) Manganese in Drinking Water | HRL23 | Acute | ND | — |
| Short-term | 100 | Developmental;Nervous system | ||
| Subchronic | ND | — | ||
| Chronic | ND | — | ||
| Cancer | NA | — | ||
| Mestranol 72-33-3 Toxicological Summary for Mestranol (PDF) Information Sheet: 17α-Ethinylestradiol and Mestranol and Drinking Water (PDF) | RAA16 | Acute | ND | — |
| Short-term | 0.0007 | Developmental (E);Female Reproductive system (E);Male Reproductive system (E) | ||
| Subchronic | 0.0002 | Developmental | ||
| Chronic | 0.0002** | Developmental | ||
| Cancer | ND | — | ||
| Methanol 67-56-1 | HRL94 | Chronic | 3,000 | Liver system;Nervous system |
| 2-Methyl-4-chlorophenoxyacetic acid (MCPA) 94-74-6 | HRL93 | Chronic | 3 | Liver system;Kidney system |
| Methyl ethyl ketone (MEK, 2-butanone) 78-93-3 | HRL94 | Chronic | 4,000 | Developmental |
| Methyl isobutyl ketone (MIBK) 108-10-1 | HRL94 | Chronic | 300 | Liver system;Kidney system |
| Methyl tert-butyl ether (MTBE) 1634-04-4 Toxicological Summary for Methyl tert-butyl ether (MTBE) (PDF) Information Sheet for Methyl tert-butyl ether (MTBE) and Drinking Water (PDF) | RAA13 | Acute | ND | — |
| Short-term | 700 | Liver system;Nervous system;Kidney system | ||
| Subchronic | 700* | Liver system;Nervous system;Kidney system | ||
| Chronic | 700* | Liver system;Nervous system;Kidney system | ||
| Cancer | 60 | Cancer | ||
| 2-Methylnaphthalene 91-57-6 Toxicological Summary for 2-Methylnaphthalene (PDF) Information Sheet: 2-Methylnaphthalene and Drinking Water (PDF) | RAA13 | Acute | ND | — |
| Short-term | ND | — | ||
| Subchronic | ND | — | ||
| Chronic | 8 | Respiratory system | ||
| Cancer | ND | — | ||
| 2-Methylphenol (o-cresol) 95-48-7 | HRL93 | Chronic | 30 | Nervous system |
| 3-Methylphenol (m-cresol) 108-39-4 | HRL93 | Chronic | 30 | Nervous system |
| 4-Methylphenol (p-cresol) 106-44-5 | HRL94 | Chronic | 3 | None |
| Metolachlor and s-Metolachlor 51218-45-2; 87392-12-9 Toxicological Summary for Metolachlor and s-Metolachlor (PDF) Information Sheet: Metolachlor and Drinking Water (PDF) | HRL23 | Acute | ND | — |
| Short-term | 300 | Developmental | ||
| Subchronic | 300* | Developmental | ||
| Chronic | 300* | Developmental | ||
| Cancer | NA | — | ||
| Metolachlor ESA 171118-09-5 (degradate of Metolachlor) Toxicological Summary for Metolachlor ESA (PDF) Information Sheet: Metolachlor ESA/OXA and Drinking Water (PDF) | HRL23 | Acute | ND | — |
| Short-term | ND | — | ||
| Subchronic | 7,000 | Liver system | ||
| Chronic | 1,000 | Liver system | ||
| Cancer | NA | — | ||
| Metolachlor OXA 152019-73-3 (degradate of Metolachlor) Toxicological Summary for Metolachlor OXA (HBV 2020) (PDF) Information Sheet: Metolachlor ESA/OXA and Drinking Water (PDF) | HRL23 | Acute | ND | — |
| Short-term | 5,000 | None | ||
| Subchronic | 5,000* | None | ||
| Chronic | 1,000 | None | ||
| Cancer | NA | — | ||
| Metribuzin 21087-64-9 Toxicological Summary for Metribuzin (PDF) See also degradates: Metribuzin DA, DK, and DADK (PDF) | HRL13 | Acute | 30 | Developmental;Nervous system |
| Short-term | 10 | Thyroid (E) | ||
| Subchronic | 10* | Thyroid (E) | ||
| Chronic | 10* | Thyroid (E) | ||
| Cancer | NA | — | ||
| Metribuzin DA, DK, and DADK 35045-02-4; 56507-37-0;52236-30-3 Toxicological Summary for Metribuzin Degradates DA, DK, and DADK (PDF) Information Sheet: Metribuzin Degradates in Drinking Water (PDF) | RAA12 | Acute | 30 | Developmental;Nervous system |
| Short-term | 10 | Thyroid (E) | ||
| Subchronic | 10* | Thyroid (E) | ||
| Chronic | 10* | Thyroid (E) | ||
| Cancer | NA | — | ||
| Microcystin-LR 101043-37-2 Toxicological Summary for Microcystin-LR (PDF) Information Sheet: Microcystin-LR in Drinking Water (PDF) | HBV15 | Acute | NA | — |
| Short-term | 0.1 | Liver System | ||
| Subchronic | 0.1* | Liver System | ||
| Chronic | 0.1 | Liver System | ||
| Cancer | NA | — | ||
| Go to > top . | ||||
| Naphthalene 91-20-3 Toxicological Summary for Naphthalene (PDF) | HRL13 | Acute | 70 | Nervous system |
| Short-term | 70 | Nervous system | ||
| Subchronic | 70* | Nervous system | ||
| Chronic | 70 | Nervous system;Spleen | ||
| Cancer | NA | — | ||
| Nickel, soluble salts 7440-02-0 | HRL93 | Chronic | 100 | None |
| Nitrate (as nitrogen) 14797-55-8 | HRLMCL | Acute | 10,000 | see USEPA Inorganic Chemicals table |
| N-Nitrosodimethylamine (NDMA) 62-75-9 Toxicological Summary for N-Nitrosodimethylamine (NDMA) (PDF) Information Sheet: N- Nitrosodimethylamine and Water (PDF) | HBV17 | Acute | ND | — |
| Short-term | ND | — | ||
| Subchronic | ND | — | ||
| Chronic | ND | — | ||
| Cancer | 0.005 | Cancer | ||
| N-Nitrosodiphenylamine 86-30-6 | HRL93 | Cancer | 70 | Cancer |
| Nonylphenol 84852-15-3 Toxicological Summary for p-Nonylphenol, branched isomers (PDF) Information Sheet: Nonylphenols and Drinking Water (PDF) | HRL23 | Acute | ND | — |
| Short-term | 100 | Developmental;Female reproductive system | ||
| Subchronic | 40 | Kidney system | ||
| Chronic | 20 | Kidney system | ||
| Cancer | NA | — | ||
| 4-**tert-Octylphenol* 140-66-9 [Toxicological Summary for 4-tert*-Octylphenol (PDF)](/communities/environment/risk/docs/guidance/gw/octylphenol.pdf) Information Sheet: Octylphenol and Drinking Water (PDF) | HRL23 | Acute | ND | — |
| Short-term | 100 | Developmental | ||
| Subchronic | 100* | Developmental | ||
| Chronic | 100* | Developmental | ||
| Cancer | NA | — | ||
| Pentachlorophenol (PCP) 87-86-5 Toxicological Summary for Pentachlorophenol (PCP) (PDF) Information Sheet: Pentachlorophenol and Drinking Water (PDF) | HRL15 | Acute | 7 | Developmental;Thyroid (E) |
| Short-term | 7 | Developmental (E);Thyroid (E) | ||
| Subchronic | 7* | Developmental (E);Liver system;Immune system;Male Reproductive system;Thyroid (E) | ||
| Chronic | 7* | Developmental (E);Liver system;Immune system;Male Reproductive system;Thyroid (E) | ||
| Cancer | 0.3 | Cancer | ||
| Perfluorobutane sulfonate (PFBS) 45187-15-3; 375-73-5;29420-49-3; 68259-10-9;60453-92-1 Toxicological Summary for Perfluorobutane sulfonate (PFBS) (PDF) Information Sheet: PFBS and Drinking Water (PDF) | HRL23 | Acute | ND | — |
| Short-term | 0.1 | Thyroid (E) | ||
| Subchronic | 0.1* | Thyroid (E) | ||
| Chronic | 0.1* | Thyroid (E) | ||
| Cancer | NA | — | ||
| Perfluorobutanoate (PFBA) 45048-62-2; 375-22-4 Toxicological Summary for Perfluorobutanoate (PFBA) (PDF) Information Sheet: PFBA and Drinking Water (PDF) | HRL18 | Acute | ND | — |
| Short-term | 7 | Liver system;Thyroid (E) | ||
| Subchronic | 7* | Liver system;Thyroid (E) | ||
| Chronic | 7* | Liver system;Thyroid (E) | ||
| Cancer | NA | — | ||
| Perfluorohexane sulfonate (PFHxS) 108427-53-8; 355-46-4;3871-99-6 Toxicological Summary for Perfluorohexane sulfonate (PFHxS) (PDF) Information Sheet: PFHxS and Groundwater (PDF) Technical Note on Additivity Calculations and Cumulative Risk for PFHxS (PDF) | HRL23 | Acute | ND | — |
| Short-term | 0.047 | Liver system;Thyroid (E) | ||
| Subchronic | 0.047 | Liver system;Thyroid (E) | ||
| Chronic | 0.047 | Liver system;Thyroid (E) | ||
| Cancer | NA | — | ||
| Perfluorohexanoate (PFHxA) 92612-52-7; 307-24-4;21615-47-4; 2923-26-4 Toxicological Summary for Perfluorohexanoate (PFHxA) (PDF) | HRL23 | Acute | ND | — |
| Short-term | 0.2 | Developmental; Thyroid (E) | ||
| Subchronic | 0.2* | Developmental;Thyroid (E) | ||
| Chronic | 0.2* | Developmental;Thyroid (E) | ||
| Cancer | NA | — | ||
| Perfluorooctanoate (PFOA) 45285-51-6; 335-67-1;335-66-0; 3825-26-1;2395-00-8; 335-93-3;335-95-5 Toxicological Summary for Perfluorooctanoate (PFOA) (PDF) Information Sheet: PFOA and Drinking Water (PDF) Toxicokinetic Model Description | HRL18*** | Acute | NA | — |
| Short-term | 0.035 | Developmental;Liver system;Immune system;Kidney system | ||
| Subchronic | 0.035 | Developmental;Liver system;Immune system;Kidney system | ||
| Chronic | 0.035 | Developmental;Liver system;Immune system;Kidney system | ||
| Cancer | NA | — | ||
| Perfluorooctanoate (PFOA) 45285-51-6; 335-67-1; 3825-26-1;2395-00-8; 335-95-5;335-93-3 Toxicological Summary for Perfluorooctanoate (PFOA) 2024 (PDF) Information Sheet: PFOA and Water (PDF) Toxicokinetic Model Description | HBV24 | Acute | NA | — |
| Short-term | 0.00024 | Developmental;Liver system;Immune system | ||
| Subchronic | 0.00024 | Developmental;Liver system;Immune system | ||
| Chronic | 0.00024 | Developmental;Liver system;Immune system | ||
| Cancer | 0.0000079 | Cancer | ||
| Perfluorooctane Sulfonate (PFOS) and Salts 45298-90-6; 1763-23-1;29081-56-9; 70225-14-8;2795-39-3; 29457-72-5 Toxicological Summary for Perfluorooctane Sulfonate (PFOS) and Salts (PDF) | HRL09*** | Acute | ND | — |
| Short-term | ND | — | ||
| Subchronic | ND | — | ||
| Chronic | 0.3 | Developmental; Liver system;Thyroid (E) | ||
| Cancer | NA | — | ||
| Perfluorooctane Sulfonate (PFOS) 45298-90-6; 1763-23-1;29081-56-9; 70225-14-8;2795-39-3; 29457-72-5 Toxicological Summary for Perfluorooctane Sulfonate (PFOS) (2024) (PDF) Information Sheet: PFOS and Drinking Water (PDF) | HBV24 | Acute | NA | — |
| Short-term | 0.0023 | Developmental;Liver system;Immune system | ||
| Subchronic | 0.0023 | Developmental;Liver system;Immune system | ||
| Chronic | 0.0023 | Developmental;Liver system;Immune system | ||
| Cancer | 0.0076 | Cancer | ||
| Phenol 108-95-2 | HRL93 | Chronic | 4,000 | Developmental |
| Picloram 1918-02-1 | HRL93 | Chronic | 500 | Liver system |
| Polychlorinated biphenyls (PCBs) 1336-36-3 | HRL94 | Cancer | 0.04 | Cancer |
| Prometon 1610-18-0 | HRL93 | Chronic | 100 | None |
| Propachlor 1918-16-7 | HRL93 | Chronic | 90 | None |
| Pyraclostrobin 175013-18-0 Toxicological Summary for Pyraclostrobin (PDF) Information Sheet: Pyraclostrobin in Drinking Water (PDF) | HBV16 | Acute | 300 | Developmental;Female Reproductive system |
| Short-term | 100 | Developmental;Female Reproductive system;Gastrointestinal system;Spleen | ||
| Subchronic | 100 | Developmental;Female Reproductive system;Gastrointestinal system;Blood system;Liver system;Immune system;Spleen | ||
| Chronic | 100** | Developmental;Female Reproductive system;Gastrointestinal system;Blood system;Liver system;Immune system;Spleen | ||
| Cancer | NA | — | ||
| Pyrene 129-00-0 Toxicological Summary for Pyrene (PDF) Information Sheet: Pyrene in Drinking Water (PDF) | HRL18 | Acute | ND | — |
| Short-term | ND | — | ||
| Subchronic | 90 | Kidney system | ||
| Chronic | 50 | Kidney system | ||
| Cancer | NA | — | ||
| Quinoline 91-22-5 Toxicological Summary for Quinoline (PDF) Information Sheet: Quinoline and Groundwater (PDF) | HRL23 | Acute | ND | — |
| Short-term | ND | — | ||
| Subchronic | ND | — | ||
| Chronic | 4 | Blood system;Liver system;Kidney system;Respiratory system;Spleen | ||
| Cancer | 0.03 | Cancer | ||
| Selenium 7782-49-2 | HRL93 | Chronic | 30 | None |
| Silver 7440-22-4 | HRL93 | Chronic | 30 | None |
| Simazine 122-34-9 | HRLMCL | Chronic | 4 | see USEPA Organic Chemicals table |
| Strontium 7440-24-6 Toxicological Summary for Strontium (PDF) Information Sheet: Strontium and Groundwater (PDF) | RAA19 | Acute | ND | — |
| Short-term | 3000 | Developmental;Skeletal | ||
| Subchronic | 3000* | Developmental;Skeletal | ||
| Chronic | 3000* | Developmental;Skeletal | ||
| Cancer | NA | — | ||
| Sulfamethazine 57-68-1; 1981-58-4 Toxicological Summary for Sulfamethazine (PDF) Information Sheet: Sulfonamide Antibiotics and Drinking Water (PDF) | HRL15 | Acute | ND | — |
| Short-term | 100 | Thyroid | ||
| Subchronic | 100* | Thyroid | ||
| Chronic | 100* | Thyroid | ||
| Cancer | NA | — | ||
| Sulfamethoxazole 723-46-6 Toxicological Summary for Sulfamethoxazole (PDF) Information Sheet: Sulfonamide Antibiotics and Drinking Water (PDF) | RAA13 | Acute | ND | — |
| Short-term | 100 | Thyroid | ||
| Subchronic | 100* | Thyroid | ||
| Chronic | 100* | Thyroid | ||
| Cancer | NA | — | ||
| 1,1,1,2-Tetrachloroethane 630-20-6 | HRL93 | Chronic | 70 | Kidney system;Liver system |
| 1,1,2,2-Tetrachloroethane 79-34-5 | HRL94 | Cancer | 2 | Cancer |
| Tetrachloroethylene (PERC or PCE) 127-18-4 Toxicological Summary for Tetrachloroethylene (PDF) Information Sheet: Tetrachloroethylene (PCE) and Drinking Water (PDF) | HRL23 | Acute | ND | — |
| Short-term | ND | — | ||
| Subchronic | 7 | Nervous system | ||
| Chronic | 7** | Nervous system | ||
| Cancer | 4 | Cancer | ||
| Go to > top . | ||||
| Tetrahydrofuran 109-99-9 Toxicological Summary for Tetrahydrofuran (PDF) Information Sheet: Tetrahydrofuran and Drinking Water (PDF) | HRL18 | Acute | ND | — |
| Short-term | 600 | Developmental | ||
| Subchronic | 600* | Developmental | ||
| Chronic | 600* | Developmental | ||
| Cancer | NA | — | ||
| Thallium salts 7440-28-0 | HRL94 | Chronic | 0.6 | Liver system |
| Thiamethoxam 153719-23-4 Toxicological Summary for Thiamethoxam (PDF) Information Sheet: Thiamethoxam and Drinking Water (PDF) | HRL18 | Acute | ND | — |
| Short-term | 400 | Developmental;Female reproductive system;Liver system | ||
| Subchronic | 200 | Male reproductive system | ||
| Chronic | 200** | Male reproductive system | ||
| Cancer | NA | — | ||
| Tin 7440-31-5 | HRL94 | Chronic | 4,000 | Liver system;Kidney system |
| Toluene 108-88-3 Toxicological Summary for Toluene (PDF) Information Sheet: Toluene and Groundwater (PDF) | HRL23 | Acute | ND | — |
| Short-term | 70 | Immune system;Nervous system | ||
| Subchronic | 70* | Immune system;Nervous system | ||
| Chronic | 70* | Immune system;Nervous system | ||
| Cancer | NA | — | ||
| Total Petroleum Hydrocarbon. See Other Guidance: Chemical Specific | ||||
| Toxaphene 8001-35-2 | HRL93 | Cancer | 0.3 | Cancer |
| 1,2,4-Trichlorobenzene 120-82-1 Toxicological Summary for 1,2,4-Trichlorobenzene (PDF) | HRL13 | Acute | ND | — |
| Short-term | 100 | Liver system;Adrenal (E);Blood system | ||
| Subchronic | 100* | Liver system;Adrenal (E);Blood system | ||
| Chronic | 100 | Liver system;Adrenal (E);Kidney system | ||
| Cancer | 4 | Cancer | ||
| 1,3,5-Trichlorobenzene 108-70-3 Toxicological Summary for 1,3,5-Trichlorobenzene (PDF) | RAA12 | Acute | ND | — |
| Short-term | 100 | Liver system;Adrenal (E);Blood System | ||
| Subchronic | 100* | Liver system;Adrenal (E);Blood system | ||
| Chronic | 100 | Liver system;Adrenal (E);Kidney system | ||
| Cancer | 4 | Cancer | ||
| 1,1,1-Trichloroethane 71-55-6 Toxicological Summary for 1,1,1-Trichloroethane (PDF) Information Sheet: 1,1,1-Trichloroethane and Drinking Water (PDF) | HRL18 | Acute | ND | — |
| Short-term | ND | — | ||
| Subchronic | 9,000 | Liver system;Male reproductive system | ||
| Chronic | 5,000 | Liver system;Male reproductive system | ||
| Cancer | NA | — | ||
| 1,1,2-Trichloroethane 79-00-5 | HRL93 | Chronic | 3 | Immune system |
| 1,1,2-Trichloroethylene (TCE) 79-01-6 Toxicological Summary for 1,1,2-Trichloroethylene (TCE) (PDF) Technical and Application Information Information Sheet: Trichloroethylene (TCE) and Water (PDF) | HRL15 | Acute | ND | — |
| Short-term | 0.4 | Developmental;Immune | ||
| Subchronic | 0.4 | Developmental;Immune | ||
| Chronic | 0.4** | Developmental;Immune | ||
| Cancer | 2 | Cancer | ||
| Trichlorofluoromethane 75-69-4 | HRL93 | Chronic | 2,000 | None |
| 2,4,6-Trichlorophenol 88-06-2 | HRL93 | Cancer | 30 | Cancer |
| 2,4,5-Trichlorophenoxyacetic acid 93-76-5 | HRL93 | Chronic | 70 | Developmental;Blood system |
| 2-(2,4,5-Trichlorophenoxy) propionic acid 93-72-1 | HRLMCL | Chronic | 50 | see USEPA Organic Chemicals table |
| 1,2,3-Trichloropropane 96-18-4 Toxicological Summary for 1,2,3-Trichloropropane (PDF) Information Sheet: 1,2,3-TCP in Drinking Water (PDF) | HRL13 | Acute | 7 | Developmental |
| Short-term | 7 | Developmental | ||
| Subchronic | 7* | Developmental | ||
| Chronic | 7* | Developmental | ||
| Cancer | 0.003 | Cancer | ||
| 1,1,2-Trichloro-1,2,2-trifluoroethane 76-13-1 | HRL93 | Chronic | 200,000 | None |
| Triclocarban 101-20-2 Toxicological Summary for Triclocarban (PDF) Information Sheet: Triclocarban and Drinking Water (PDF) | RAA13 | Acute | ND | — |
| Short-term | ND | — | ||
| Subchronic | ND | — | ||
| Chronic | 100 | Blood system;Liver system;Male reproductive system;Kidney system | ||
| Cancer | NA | — | ||
| Triclosan 3380-34-5 Toxicological Summary for Triclosan (PDF) Information Sheet: Triclosan and Drinking Water (PDF) | HRL15 | Acute | ND | — |
| Short-term | 50 | Developmental;Liver system;Thyroid (E);Female Reproductive system (E) | ||
| Subchronic | 50* | Developmental;Liver system;Thyroid (E);Female Reproductive system (E) | ||
| Chronic | 50* | Developmental;Liver system;Thyroid (E);Female Reproductive system (E) | ||
| Cancer | NA | — | ||
| 1,2,3-Trimethylbenzene 526-73-8 Toxicological Summary for 1,2,4-Trimethylbenzene; 1,3,5-Trimethylbenzene; and 1,2,3-Trimethylbenzene (PDF) Information Sheet: Trimethylbenzenes and Groundwater (PDF) | HRL23 | Acute | ND | — |
| Short-term | 30 | Nervous system | ||
| Subchronic | 30* | Nervous system | ||
| Chronic | 30* | Nervous system | ||
| Cancer | NA | — | ||
| 1,2,4-Trimethylbenzene 95-63-6 Toxicological Summary for 1,2,4-Trimethylbenzene; 1,3,5-Trimethylbenzene; and 1,2,3-Trimethylbenzene (PDF) Information Sheet: Trimethylbenzenes and Groundwater (PDF) | HRL23 | Acute | ND | — |
| Short-term | 30 | Nervous system | ||
| Subchronic | 30* | Nervous system | ||
| Chronic | 30* | Nervous system | ||
| Cancer | NA | — | ||
| 1,3,5-Trimethylbenzene 108-67-8 Toxicological Summary for 1,2,4-Trimethylbenzene; 1,3,5-Trimethylbenzene; and 1,2,3-Trimethylbenzene (PDF) Information Sheet: Trimethylbenzenes and Groundwater (PDF) | HRL23 | Acute | ND | — |
| Short-term | 30 | Nervous system | ||
| Subchronic | 30* | Nervous system | ||
| Chronic | 30* | Nervous system | ||
| Cancer | NA | — | ||
| 1,3,5-Trinitrobenzene 99-35-4 | HRL93 | Chronic | 0.3 | None |
| Tris(2-butoxyethyl) phosphate (TBEP) 78-51-3 Toxicological Summary for Tris(2-butoxyethyl) phosphate (PDF) | HRL23 | Acute | ND | — |
| Short-term | 30 | Liver system | ||
| Subchronic | 30* | Liver system | ||
| Chronic | 30 | Liver system | ||
| Cancer | NA | — | ||
| Tris(2-chloroethyl) phosphate (TCEP) 115-96-8 Toxicological Summary for Tris(2-chloroethyl)phosphate (PDF) Information Sheet: TCEP in Drinking Water (PDF) | HRL13 | Acute | ND | — |
| Short-term | 300 | Developmental;Nervous system;Kidney system | ||
| Subchronic | 200 | Kidney system | ||
| Chronic | 200** | Kidney system | ||
| Cancer | 5 | Cancer | ||
| Tris(1,3-dichloroisopropyl)phosphate (TDCPP) 13674-87-8 Toxicological Summary for Tris(1,3-dichloroisopropyl)phosphate (PDF) Information Sheet: TDCPP and Drinking Water (PDF) | HRL23 | Acute | ND | — |
| Short-term | ND | — | ||
| Subchronic | 20 | Liver system;Kidney system | ||
| Chronic | 8 | Kidney system;Male reproductive system | ||
| Cancer | 0.8 | Cancer | ||
| Vanadium 7440-62-2 | HRL94 | Chronic | 50 | None |
| Venlafaxine 93413-69-5; 99300-78-4 Toxicological Summary for Venlafaxine (PDF) Information Sheet: Venlafaxine and Desvenlafaxine and Drinking Water (PDF) | HRL23 | Acute | ND | — |
| Short-term | 10 | Developmental;Gastrointestinal system;Male reproductive system;Nervous system (E) | ||
| Subchronic | 10* | Developmental;Gastrointestinal system;Male reproductive system;Nervous system (E) | ||
| Chronic | 10* | Developmental;Gastrointestinal system;Male reproductive system;Nervous system (E) | ||
| Cancer | NA | — | ||
| Vinyl Chloride 75-01-4 Toxicological Summary for Vinyl Chloride (PDF) Information Sheet: Vinyl Chloride and Drinking Water (PDF) | HRL18 | Acute | ND | — |
| Short-term | ND | — | ||
| Subchronic | 90 | Liver system | ||
| Chronic | 10 | Liver system | ||
| Cancer | 0.2 | Cancer | ||
| Xylenes 1330-20-7 Toxicological Summary for Xylenes (PDF) Information Sheet: Xylenes and Groundwater (PDF) | HRL23 | Acute | 700 | Nervous system |
| Short-term | 300 | Developmental;Nervous system | ||
| Subchronic | 300 | Developmental;Nervous system;Kidney system | ||
| Chronic | 300** | Developmental;Nervous system;Kidney system | ||
| Cancer | NA | — | ||
| Zinc 7440-66-6 | HRL94 | Chronic | 2,000 | None |
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NA - Not Applicable
ND - Not derived due to insufficient information
None - Nonspecific effects that could not be attributed to an organ system
(E) = Endocrine mediated effect on the specified target organ
*Set at short-term value
**Set at subchronic value
***Dual guidance applies: See [Dual Guidance for Drinking Water](/communities/environment/risk/guidance/dualguidance.html)
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